| Identification | Back Directory | [Name]
Amino-PEG24-acid | [CAS]
2563873-76-5 | [Synonyms]
H2N-PEG24-CH2CH2COOH/
Propanoic acid, 3-[(71-amino-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69-tricosaoxahenheptacont-1-yl)oxy]- | [Molecular Formula]
C51H103NO26 | [MOL File]
2563873-76-5.mol | [Molecular Weight]
1146.37 |
| Chemical Properties | Back Directory | [Boiling point ]
952.9±65.0 °C(Predicted) | [density ]
1.122±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.28±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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