| Identification | Back Directory | [Name]
1-Piperazinepropanamide, 4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]octyl]- | [CAS]
2550393-21-8 | [Synonyms]
1-Piperazinepropanamide, 4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]octyl]- | [Molecular Formula]
C46H54ClFN8O8 | [MOL File]
2550393-21-8.mol | [Molecular Weight]
901.42 |
| Hazard Information | Back Directory | [Description]
MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC?) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. It is bioavailable in mice following ip administration. | [storage]
Store at -20°C |
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