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ChemicalBook--->CAS DataBase List--->253426-24-3

253426-24-3

253426-24-3 Structure

253426-24-3 Structure
IdentificationBack Directory
[Name]

AVE8062A
[CAS]

253426-24-3
[Synonyms]

AC 7700
AVE8062A
Ombrabulin HCl
AC7700 (hydrochloride)
AVE8062 (hydrochloride)
Ombrabulin (AVE8062) HCl
Ombrabulin (hydrochloride)
Ombrabulin (AVE8062) hydrochloride
Ombrabulin hydrochloride >=98% (HPLC)
[EINECS(EC#)]

682-340-5
[Molecular Formula]

C21H27ClN2O6
[MOL File]

253426-24-3.mol
[Molecular Weight]

438.902
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble; Ethanol: soluble
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Danger
[Hazard statements ]

H360-H372-H351-H362-H341
[Precautionary statements ]

P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501-P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
[RTECS ]

TX1404540
Hazard InformationBack Directory
[General Description]

Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound.
[Biochem/physiol Actions]

Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.
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