| Identification | Back Directory | [Name]
Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- | [CAS]
2522599-79-5 | [Synonyms]
CAY10771
Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- | [Molecular Formula]
C28H25Cl3N2O4 | [MOL File]
2522599-79-5.mol | [Molecular Weight]
559.87 |
| Hazard Information | Back Directory | [Biological Activity]
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1 It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. | [References]
1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020)
|
|
| Company Name: |
ChemeGen 中國(guó)
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|