| Identification | Back Directory | [Name]
Slv320 | [CAS]
251945-92-3 | [Synonyms]
Slv320
SC-204288
Derenofylline
SLV320 >=98% (HPLC)
SLV320; SLV-320; SLV 320; DERENOFYLLINE
4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
(1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol
Cyclohexanol, 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-
Cyclohexanol, 4-((2-phenyl-1H-pyrrolo(2,3-D)pyrimidin-4-yl)amino)-, trans- | [Molecular Formula]
C18H20N4O | [MOL File]
251945-92-3.mol | [Molecular Weight]
308.38 |
| Chemical Properties | Back Directory | [Boiling point ]
532.3±60.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Soluble to 100 mM in DMSO and to 50 mM in ethanol | [form ]
Powder | [pka]
15.15±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Derenofylline is an adenosine A1 receptor antagonist (Ki = 1 nM). It is selective for adenosine A1 over A2A, A2B, and A3 receptors (Kis = 398, 3,981, and 200 nM, respectively). It decreases adenosine A1 receptor-mediated adenosine-induced bradycardia in rats (ED50 = 0.49 mg/kg) but reduces A2 receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC50 = 58.6 nM) in an adenosine A1 receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 μM. | [Uses]
SLV 320 is an A1 antagonist. | [storage]
Store at RT |
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DC Chemicals
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