| Identification | Back Directory | [Name]
2511248-11-4 | [CAS]
2511248-11-4 | [Synonyms]
DHODH-IN-16
6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7-fluoro-4-isopropyl-2-(o-tolyl)isoquinolin-1(2H)-one | [Molecular Formula]
C24H25FN4O3 | [MOL File]
2511248-11-4.mol | [Molecular Weight]
436.48 |
| Chemical Properties | Back Directory | [Boiling point ]
602.6±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (229.11 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.54±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1].
DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM[1]. | [storage]
Store at -20°C | [References]
[1]. Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1. |
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