| Identification | Back Directory | [Name]
Poly(1-vinylpyrrolidone-co-vinyl acetate) | [CAS]
25086-89-9 | [Synonyms]
e335
e535
i535
i635
i735
s630
pvp-va
kolima10
kolima35
kolima75
gaf-s630
ganexe535
gantronpvp
gantrons630
gantrons860
copolyvidon
pvp/va-s630
pvp-va-e735
luviskolva64
polectron845
kollidonva64
luviskolva28i
luviskolva37e
luviskolva37i
luviskolva55e
luviskolva55i
luviskolva73e
pvp/vacopolymer
PVP-VAcopolymer
VP/VA COPOLYMER
Povidone Va S-630
N-vinyl-y-pyrrolidone
PVP-A Copolymer Series
1-Vinylpyrrolidone-2(NVP)
Copolymer3:7,50%inethanol
N-Vinyl-Gamma-Pyrrolidone
Copolymerization d ketone
copovidone, pvp/va copolymer
(CopolyMer, 7:3) (50% in Ethanol)
Vinylacetate-N-vinylpyrrolidinone
POLYVINYLPYRROLIDONE-VINYL ACETATE
Vinylpyrrolidon-Vinylacetat-Copolymer
POLY(N-VINYLPYRROLIDONE/VINYL ACETATE)
Vinyl acetate-Vinylpirrolidone copolymer
poly(1-vinylpyrrolidone - vinyl acetate)
VINYLPYRROLIDONE-VINYL ACETATE COPOLYMER
POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE)
N-VINYLPYRROLIDONE/VINYL ACETATE COPOLYMER
POLYVINYLPYRROLIDONE-VINYLACETATECOPOLYMER
copolyresinvinylketopyrrolidine/vinylacetate
vinylpyrrolidone/vinylacetatecopolymer(solid)
1-Vinyl-2-pyrrolidone-vinyl acetate copolymer
Vinyl ketopyrrolidine/vinyl acetate copolymer
Poly(1-vinylpyrrolidone-co-Vinyl Acetate)
Vinyl acetate/N-Vinyl-2-pyrrolidinone copolymer
poly(1-vinylpyrrolidone-co-vinyl acetate) solution
POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE ), POWDER
Ethenyl acetate, polymer with 1-ethenyl-2-pyrrolidinone
aceticacidvinylester,polymerwith1-vinyl-2-pyrrolidinone
2-Pyrrolidinone, 1-ethenyl-, polymer with ethenyl acetate
Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (50% in Ethanol)
aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone
aceticacidethenylestercopolymerwith1-ethenyl-2-pyrrolidinone
Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone
Vinylpyrrolidone/Vinylacetate copolymer(PVP/VA,Copolyvidone)
POLYVINYLPYRROLIDONE-VINYL ACETATE (COPOLYMER 3: 7) 50% IN ETOH
POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE ), 50 WT. % SOLUTION IN 2-PROPANOL
Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol)
Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 3:7) (50% in Ethanol)
Poly(1-vinylpyrrolidone-co-vinyl acetate) average Mw ~50,000 (GPC vs. poly(ethylene oxide)), powder | [EINECS(EC#)]
200-001-8 | [Molecular Formula]
C30H45N3O9X2 | [MDL Number]
MFCD00134018 | [MOL File]
25086-89-9.mol | [Molecular Weight]
591.69 |
| Chemical Properties | Back Directory | [Appearance]
white powder | [density ]
1.27 g/mL at 25 °C(lit.)
| [Tg]
108 | [refractive index ]
1.4300 to 1.4380 | [Fp ]
72 °F
| [solubility ]
Greater than 10% solubility in 1,4-butanediol, glycerol,
butanol, chloroform, dichloromethane, ethanol (95%),
glycerol, methanol, polyethylene glycol 400, propan-2-ol,
propanol, propylene glycol, and water. Less than 1% solubility
in cyclohexane, diethyl ether, liquid paraffin, and pentane. | [form ]
powder
| [color ]
White | [Stability:]
Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents. | [InChI]
InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3 | [InChIKey]
FYUWIEKAVLOHSE-UHFFFAOYSA-N | [SMILES]
C(N1CCCC1=O)=C.O(C=C)C(=O)C | [LogP]
0.370 (est) | [EPA Substance Registry System]
Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone(25086-89-9) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
Poly(1-vinylpyrrolidone-co-vinyl acetate) | [Production Methods]
Copovidone is manufactured by free-radical polymerization of
vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is
conducted in an organic solvent owing to the insolubility of vinyl
acetate in water. | [General Description]
～1:2.4 mole ratio of VP:VA | [Pharmaceutical Applications]
Copovidone is used as a tablet binder, a film-former, and as part of
the matrix material used in controlled-release formulations. In
tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often
added to coating solutions as a film-forming agent. It provides good
adhesion, elasticity, and hardness, and can be used as a moisture
barrier. | [Safety Profile]
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx. | [Safety]
Copovidone is used widely in pharmaceutical formulations and is
generally regarded as nontoxic. However, it is moderately toxic by
ingestion, producing gastric disturbances. It has no irritating or
sensitizing effects on the skin. A study was conducted to look at the
carcinogenicity and chronic toxicity of copovidone (Kollidon VA
64) in Wistar rats and Beagle dogs. The results of these studies
demonstrated the absence of any significant toxicological findings
of high dietary levels of copodivone in rats and dogs, resulting in noobserved-
adverse-effect levels of 2800 mg/kg body-weight/day in
rats and 2500 mg/kg body-weight/day in dogs, the highest doses
tested.
LD50 (rat, oral): >0.63 g/kg | [Solubility in organics]
Acetone, chloroform, methanol, THF, water | [Solubility in organics]
THF (above 68C) | [Solubility in organics]
THF, water | [storage]
Copovidone is stable and should be stored in a well-closed container
in a cool, dry place. | [Incompatibilities]
Copovidone is compatible with most organic and inorganic
pharmaceutical ingredients. When exposed to high water levels,
copovidone may form molecular adducts with some materials; see
Crospovidone and Povidone. | [Regulatory Status]
Copovidone is included in the FDA Inactive Ingredients Database
(oral tablets, oral film-coated tablets, sustained action). |
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