| Identification | Back Directory | [Name]
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA | [CAS]
249889-64-3 | [Synonyms]
CS-1473
SB 334867
SB 334867A
SB334867 HCl
Zinc00008794
SB-334867 hydrochloride
SB 334867 hydrochloride NEW
SB 334867A; SB334867; SB 334867
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride) | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C17H13N5O2 | [MDL Number]
MFCD06411602 | [MOL File]
249889-64-3.mol | [Molecular Weight]
319.32 |
| Chemical Properties | Back Directory | [Melting point ]
>235°C (dec.) | [storage temp. ]
Desiccate at RT | [solubility ]
Dichloromethane (Slightly), DMSO (Slightly) | [form ]
Solid | [color ]
White |
| Hazard Information | Back Directory | [Uses]
SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability. | [Definition]
ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative. | [Biological Activity]
Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo . | [storage]
Store at -20°C | [References]
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452. |
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SPIRO PHARMA
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www.spiropharma.com.cn |
| Company Name: |
Musechem
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+1-800-259-7612 |
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www.musechem.com |
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