| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 125 mg/mL (284.17 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 hydrochloride can induce HbF protein expression in cell and murine models. FTX-6058 hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].
FTX-6058 hydrochloride inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2]. | [References]
[1]. Boerner LK. Virtual meeting delivers first time drug structures. April 12, 2021. |
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