| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
8.85±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.03 μM).1 It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells. | [References]
1.Re?ing, N., S?nnichsen, M., Osko, J.D., et al.Multicomponent synthesis, binding mode, and structure-activity relationship of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groupsJ. Med. Chem.63(18)10339-10351(2020)
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| Company Name: |
ChemeGen 中國
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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