| Identification | Back Directory | [Name]
1-Piperazinecarboxylic acid, 4-[trans-4-[[6-(cyanomethyl)-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]-, methyl ester | [CAS]
2454244-02-9 | [Synonyms]
IRAK4-IN-6
1-Piperazinecarboxylic acid, 4-[trans-4-[[6-(cyanomethyl)-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]-, methyl ester | [Molecular Formula]
C25H32N10O2 | [MOL File]
2454244-02-9.mol | [Molecular Weight]
504.59 |
| Chemical Properties | Back Directory | [Boiling point ]
741.4±70.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (247.73 mM) | [form ]
Powder | [pka]
7.18±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma[1]. | [storage]
Store at -20°C | [References]
[1] Degorce SL, et al. Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors TargetingMyD88L265P Mutant Diffuse Large B Cell Lymphoma. J Med Chem. 2019 Nov 1. DOI:10.1021/acs.jmedchem.9b01346 |
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| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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