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ChemicalBook--->CAS DataBase List--->2448173-47-3

2448173-47-3

2448173-47-3 Structure

2448173-47-3 Structure
IdentificationBack Directory
[Name]

Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester
[CAS]

2448173-47-3
[Synonyms]

Menin-MLL inhibitor 20
Menin-MLL inhibitor 20,MRN73473
Carbamic acid, N-[(3R)-1-[[2-[[[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]amino]carbonyl]-4-pyridinyl]methyl]-3-piperidinyl]-, 1,1-dimethylethyl ester
[Molecular Formula]

C33H40N8O4
[MDL Number]

MFCD34574791
[MOL File]

2448173-47-3.mol
[Molecular Weight]

612.72
Chemical PropertiesBack Directory
[density ]

1.34±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 33.33 mg/mL (54.40 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[pka]

11.80±0.70(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6)[1]. The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease[1].
[References]

[1]. Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.
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