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ChemicalBook--->CAS DataBase List--->244192-94-7

244192-94-7

244192-94-7 Structure

244192-94-7 Structure
IdentificationBack Directory
[Name]

L 748,337
[CAS]

244192-94-7
[Synonyms]

L-748
L 748,337
L748337,L-748337
N-[[3-[(2S)-3-[2-[4-(benzenesulfonamido)phenyl]ethylamino]-2-hydroxypropoxy]phenyl]methyl]acetamide
N-[[3-[(2S)-2-HYDROXY-3-[[2-[4-[(PHENYLSULFONYL)AMINO]PHENYL]ETHYL]AMINO]PROPOXY]PHENYL]METHYL]-ACETAMIDE
Acetamide, N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-
[Molecular Formula]

C26H31N3O5S
[MDL Number]

MFCD10687097
[MOL File]

244192-94-7.mol
[Molecular Weight]

497.61
Chemical PropertiesBack Directory
[storage temp. ]

Store at +4°C
[solubility ]

Soluble to 100 mM in DMSO and to 25 mM in ethanol
[form ]

Powder
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

L-748,337 is a selective competitive β3-adrenoceptor antagonist.
[Biological Activity]

Competitive β 3 -adrenoceptor antagonist that displays selectivity over β 1 and β 2 receptors (K i values are 4.0, 204 and 390 nM for β 3 -, β 2 - and β 1 -adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC 50 = 6 nM).
[storage]

Store at -20°C
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