| Identification | Back Directory | [Name]
Tinoridine | [CAS]
24237-54-5 | [Synonyms]
6H
y-3642
tinoridine
7H-thieno[2
Tinoridine USP/EP/BP
Nonflamin (free base)
ethyl 2-amino-6-benzyl-4H
Thieno(2,3-c)pyridine-3-carboxylic acid, 2-amin
2-AMINO-3-ETHOXY-CARBONYL-6-BENZYL-4,5,6,7-TETRAHYDROTHIEN.
ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate
2-amino-3-aethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridin
2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine
3-c)pyridine-3-carboxylicacid,4,5,6,7-tetrahydro-2-amino-6-benzyl-thieno(
2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine-3-carboxylicacidet
Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
ethyl 2-amino-6-(phenylmethyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylate
2-amino-6-(benzyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylic acid ethyl ester
2-Amino-6-benzyl-3-(ethoxycarbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine, Tinoridine
2-amino-6-(phenylmethyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylic acid ethyl ester
Thieno[2,3-c]pyridine-3-carboxylic acid, 2-aMino-4,5,6,7-tetrahydro-6-(phenylMethyl)-, ethyl ester
2-amino-6-(phenylmethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-ium-3-carboxylic acid ethyl ester
Thieno(2,3-c)pyridine-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-, ethyl ester (9CI) | [EINECS(EC#)]
246-102-0 | [Molecular Formula]
C17H20N2O2S | [MDL Number]
MFCD00401417 | [MOL File]
24237-54-5.mol | [Molecular Weight]
316.42 |
| Chemical Properties | Back Directory | [Melting point ]
112-113°C | [Boiling point ]
493.5±45.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
6.29±0.20(Predicted) |
| Safety Data | Back Directory | [HazardClass ]
IRRITANT | [HS Code ]
2934999090 | [Toxicity]
LD50 in mice, rats (mg/kg): 5400, >10200 orally; 1600, 1250 i.p. (Nakanishi, 1970) |
| Hazard Information | Back Directory | [Originator]
Nonflamin,Yoshitomi,Japan,1971 | [Uses]
Ethyl 2-Amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (Tinoridine) targets pantothenate synthetase which plays a significant role in the biosynthesis of pantothenate in Mycobacterium tuberculosis (MTB). | [Definition]
ChEBI: Tinoridine is a thienopyridine. | [Manufacturing Process]
A solution of 1-benzyl-4-piperidone, ethyl cyanoacetate, powdery sulfur and
morpholine in ethanol is heated moderately under reflux for about 20 minutes
to dissolve the powdery sulfur. The mixture is heated under reflux for one
further hour to complete the reaction. On standing at room temperature, the
mixture yields a precipitate. The precipitate is collected by filtration, washed
well with methanol and recrystallized from methanol to give 2-amino-6-
benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno(2,3-c)-pyridine as almost
colorless needles melting at 112° to 113°C. | [Brand name]
Tinoridine Hydrochloride
is JAN. | [Therapeutic Function]
Antiinflammatory |
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