| Identification | Back Directory | [Name]
9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- | [CAS]
2411100-70-2 | [Synonyms]
STING Agonist 12b
9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- | [Molecular Formula]
C16H15NO2 | [MOL File]
2411100-70-2.mol | [Molecular Weight]
253.3 |
| Hazard Information | Back Directory | [Biological Activity]
STING agonist 12b is an agonist of stimulator of interferon genes (STING).1 It binds to STING (Kd = 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. | [References]
1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
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ChemeGen 中國(guó)
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https://www.chemegen.com |
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