| Identification | Back Directory | [Name]
BIS(P-TOLYL)PHOSPHINE OXIDE | [CAS]
2409-61-2 | [Synonyms]
Bis(p-toL
Di-p-tolylphosphine oxide
BIS(P-TOLYL)PHOSPHINE OXIDE
Di(p-tolyl)phosphineOxide>
bis(4-methylphenyl)-oxophosphanium
Bis(4-Methylphenyl)phosphine Oxide
Bis (p-Methylphenyl) phosphine oxide
Phosphine oxide, bis(4-methylphenyl)-
1-Methyl-4-[(4-Methylphenyl)phosphoryl]benzene | [EINECS(EC#)]
808-017-2 | [Molecular Formula]
C14H15OP | [MDL Number]
MFCD01445489 | [MOL File]
2409-61-2.mol | [Molecular Weight]
230.24 |
| Chemical Properties | Back Directory | [Melting point ]
96°C(lit.) | [Boiling point ]
354.2±45.0 °C(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
powder to crystal | [color ]
White to Almost white | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C14H15OP/c1-11-3-7-13(8-4-11)16(15)14-9-5-12(2)6-10-14/h3-10,16H,1-2H3 | [InChIKey]
GCUWBTGMXUIKOB-UHFFFAOYSA-N | [SMILES]
P(=O)(C1=CC=C(C)C=C1)C1=CC=C(C)C=C1 | [CAS DataBase Reference]
2409-61-2 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
suzuki reaction | [Synthesis Reference(s)]
[1] Controllable Phosphorylation of Thioesters: Selective Synthesis of Aryl and Benzyl Phosphoryl Compounds. J. Org. Chem. 2020, 85, 22, 14653–14663. | [Synthesis]
A dried 250 mL flask was charge with p-tolylmagnesium bromide (33 mmol, 1.0 mol/L in THF) in an ice-water bath under N2. A solution of diethylphosphite (1.3 mL, 10.0 mmol) in anhydrous THF (5.0 mL) was then added dropwise over 30 min. The mixture was further stirred at ambient temperature overnight. After that, the reaction mixture was cooled to 0 °C again, and HCl (100 mL 0.1 N) was added dropwise. The mixture was extracted with dichloromethane (100 mL × 3), and the combined organic phase was washed with saturated NaCl solution, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The crude product was purified by column chromatography (EtOAc) to give the desired product BIS(P-TOLYL)PHOSPHINE OXIDE. |
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