| Identification | Back Directory | [Name]
β-Muricholic Acid | [CAS]
2393-59-1 | [Synonyms]
β-Muricholic Acid
3a,6b,7b-Trihydroxy-5b-cholanoic acid
(3α,5β,6β,7β)-3,6,7-Trihydroxycholan-24-oic acid
(3a,5b,6b,7b)-3,6,7-trihydroxy-Cholan-24-oic acid | [Molecular Formula]
C24H40O5 | [MDL Number]
MFCD00271403 | [MOL File]
2393-59-1.mol | [Molecular Weight]
408.58 |
| Chemical Properties | Back Directory | [Melting point ]
226 °C | [Boiling point ]
565.7±40.0 °C(Predicted) | [density ]
1.184±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Ethanol (Slightly,Sonicated), Methanol (Slightly), Water (Sligh | [form ]
powder | [pka]
4.76±0.10(Predicted) | [color ]
white to beige | [optical activity]
[α]/D +59 to +65°, c = 0.1 in methanol |
| Hazard Information | Back Directory | [Description]
β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.1,2 Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.3 Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.4 | [Uses]
β-Muricholic Acid is an bile acid found in urine. β-Muricholic Acid has been used in studies of down regulation of transporter protein through ubiquitin dependent protein degradation. | [Definition]
ChEBI: Beta-muricholic acid is a member of the class of muricholic acids in which the hydroxy groups at positions 6 and 7 both have beta configuration. It is a member of muricholic acids, a 6beta-hydroxy steroid and a 7beta-hydroxy steroid. It is a conjugate acid of a beta-muricholate. | [in vivo]
β-Muricholic acid (Fed chow with 0.5% β-muricholic acid for 8 weeks) prevents diet-induced or experimental cholesterol gallstones in mice[2]. | Animal Model: | 6-8 weeks, Male C57L/J mice (with a lithogenic diet (2% cholesterol and 0.5% cholic acid))[2] | | Dosage: | 0.5% β-muricholic acid | | Administration: | Fed chow with 0.5% β-muricholic acid for 8 weeks | | Result: | Decreased gallstone prevalence to 20% through significantly reducing biliary secretion rate, saturation index, and intestinal absorption of cholesterol, as well as inducing phase boundary shift and an enlarged Region E that prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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