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ChemicalBook--->CAS DataBase List--->2390475-81-5

2390475-81-5

2390475-81-5 Structure

2390475-81-5 Structure
IdentificationBack Directory
[Name]

Tetrazolo[1,5-a]pyrimidine-6-carboxamide, 4,7-dihydro-4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-
[CAS]

2390475-81-5
[Synonyms]

EB-42486
Tetrazolo[1,5-a]pyrimidine-6-carboxamide, 4,7-dihydro-4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-
[Molecular Formula]

C22H22N8O
[MOL File]

2390475-81-5.mol
[Molecular Weight]

414.46
Chemical PropertiesBack Directory
[density ]

1.41±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 250 mg/mL (603.19 mM; Need ultrasonic)
[form ]

Solid
[pka]

11.92±0.40(Predicted)
[color ]

Off-white to light yellow
Spectrum DetailBack Directory
[Spectrum Detail]

Tetrazolo[1,5-a]pyrimidine-6-carboxamide, 4,7-dihydro-4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-(2390475-81-5)1HNMR
Hazard InformationBack Directory
[Biological Activity]

EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM).
[References]

[1]. Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.
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