| Identification | Back Directory | [Name]
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- | [CAS]
2387821-46-5 | [Synonyms]
HB007
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- | [Molecular Formula]
C15H9ClN4OS | [MDL Number]
MFCD34578507 | [MOL File]
2387821-46-5.mol | [Molecular Weight]
328.78 |
| Hazard Information | Back Directory | [Biological Activity]
HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2].
HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].
HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1]. | [References]
[1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. [2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1. |
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DC Chemicals
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