| Hazard Information | Back Directory | [Biological Activity]
BI-9321 is a potent, selective, and cellularly active NSD3-PWWP1 antagonist with a Kd of 166 nM. BI-9321 is not valid for NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts the interaction of NSD3-PWWP1 with histones in U2OS cells with IC50 of 1.2 μM. | [in vitro]
BI-9321 is targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 μM. As a single agent, BI-9321 downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells. | [target]
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| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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