| Identification | Back Directory | [Name]
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT | [CAS]
23815-89-6 | [Synonyms]
RPPGF
1-5-Bradykinin
BRADYKININ (1-5)
ARG-PRO-PRO-GLY-PHE
1-5-Bradykinin (9CI)
Arg-Pro-Pro-Gly-Phe-OH
BRADYKININ FRAGMENT 1-5
39: PN: WO0112656 SEQID
H-Arg-Pro-Pro-Gly-Phe-OH
ARG-PRO-PRO-GLY-PHE ACETATE
H-ARG-PRO-PRO-GLY-PHE-OH TFA
L-Arg-L-Pro-L-Pro-Gly-L-Phe-OH
Bradykinin Fragment 1-5, ≥97% (HPLC)
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
N5-(Diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanine
Bradykinin (1-5) trifluoroacetate salt H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt | [Molecular Formula]
C27H40N8O6 | [MDL Number]
MFCD03788122 | [MOL File]
23815-89-6.mol | [Molecular Weight]
572.66 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.50±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Biologically active fragment of bradykinin | [Biochem/physiol Actions]
The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins. |
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