| Identification | Back Directory | [Name]
1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) | [CAS]
2380032-29-9 | [Synonyms]
Emlenoflast sodium
1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) | [Molecular Formula]
C19H25N4NaO3S | [MOL File]
2380032-29-9.mol | [Molecular Weight]
412.48 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, away from moisture | [solubility ]
DMSO : 240 mg/mL (584.70 mM; Need ultrasonic) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases[1][2].
MCC7840, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1].
MCC7840 (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice[2].MCC7840 (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2]. | [storage]
-20°C, away from moisture | [References]
[1]. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533. [2]. O’neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1. |
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DC Chemicals
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