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ChemicalBook--->CAS DataBase List--->2375720-38-8

2375720-38-8

2375720-38-8 Structure

2375720-38-8 Structure
IdentificationBack Directory
[Name]

LH1307
[CAS]

2375720-38-8
[Synonyms]

LH1307
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF:25.0(Max Conc. mg/mL);27.32(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);27.32(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);10.93(Max Conc. mM)
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1.
[in vitro]

C2-symmetric inhibitors 2a (LH1306) and 2b (LH1307) exhibited IC50 values of 25 and 3.0 nM, respectively, in the HTRF assay. In one cell-based coculture PD-1 signaling assay, 2a and 2b were 8.2- and 2.8-fold more potent in inhibiting PD-1 signaling than 1a and 1b, respectively._x000D_ _x000D_ Reference: J Med Chem. 2019 Aug 8;62(15):7250-7263. https://pubmed.ncbi.nlm.nih.gov/31298541/
[target]

LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1.
[storage]

Store at -20°C
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