| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2375432-47-4 | [Synonyms]
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-(19-((4R)-4-hydroxy-2-((1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide | [Molecular Formula]
C55H76N10O12S | [MOL File]
2375432-47-4.mol | [Molecular Weight]
1101.33 |
| Chemical Properties | Back Directory | [Boiling point ]
1254.3±65.0 °C(Predicted) | [density ]
1.295±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (90.80 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.41±0.46(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
MS4322 (YS43-22) is a first-in-class PRMT5 degrader and a valuable chemical tool (PROTAC) for exploring the PRMT5 functions in health and disease. | [References]
[1]. Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63(17):9977-9989. |
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