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ChemicalBook--->CAS DataBase List--->2375193-43-2

2375193-43-2

2375193-43-2 Structure

2375193-43-2 Structure
IdentificationBack Directory
[Name]

XRK3F2
[CAS]

2375193-43-2
[Synonyms]

XRK3F2
[Molecular Formula]

C23H24ClF2NO3
[MDL Number]

MFCD31812777
[MOL File]

2375193-43-2.mol
[Molecular Weight]

435.9
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 150 mg/mL (344.12 mM);Water : 0.91 mg/mL (2.09 mM)
[form ]

Solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Warning
[Hazard statements ]

H320-H372
[Precautionary statements ]

P260-P264b-P270-P314-P403-P501c
Hazard InformationBack Directory
[Biological Activity]

XRK3F2 is a p62-ZZ inhibitor that blunts multiple myeloma (MM)-induced Runx2 inhibition in vitro and induces new bone formation and remodeling in the presence of tumors in vivo.
[in vivo]

In vivo, XRK3F2 induces new bone formation and remodeling in tumors. The half-life of it in mice was 10.3 hours. In bone with multiple myeloma, it induced significant local new bone formation, but not in mice not directly inoculated with multiple myeloma cells.
[target]

TargetValue
p62-ZZ
()
[storage]

Store at -20°C
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