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ChemicalBook--->CAS DataBase List--->236754-49-7

236754-49-7

236754-49-7 Structure

236754-49-7 Structure
IdentificationBack Directory
[Name]

Azide-PEG4-Tos
[CAS]

236754-49-7
[Synonyms]

N3-PEG5-Tos
236754-49-7
Azide-PEG4-Tos
Azide-PEG5-Tos
Azido-PEG5-Tos
Azido-PEG5-OTs
N3-PEG5-TOS AZIDE-PEG5-TOS
[Molecular Formula]

C17H27N3O7S
[MDL Number]

MFCD22683295
[MOL File]

236754-49-7.mol
[Molecular Weight]

417.48
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302+H312+H332-H315-H319-H335
[Precautionary statements ]

P260-P280-P301+P312-P302+P352-P304+P340-P361+P364
Hazard InformationBack Directory
[Description]

Azide-PEG5-Tos is a crosslinking reagent with two functional groups. PEG spacer increases solubility in aqueous media. The azide(N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.
[Biological Activity]

Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs).
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

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