| Identification | Back Directory | [Name]
1,2,3,4,5,6,7,8,9-NONACHLORODECANE | [CAS]
2366268-80-4 | [Synonyms]
CP-10
1,2,3,4,5,6,7,8,9-NONACHLORODECANE | [Molecular Formula]
C44H49N13O7 | [MDL Number]
MFCD08273901 | [MOL File]
2366268-80-4.mol | [Molecular Weight]
871.94 |
| Chemical Properties | Back Directory | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 200 mg/mL (229.37 mM) | [form ]
Solid | [pka]
10.74±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1]. | [IC 50]
CDK6: 2.1 nM (DC50); Cereblon | [References]
[1] Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2. DOI:10.1021/acs.jmedchem.9b00871 |
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MedChemExpress
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