| Identification | Back Directory | [Name]
J30-8 | [CAS]
2366255-71-0 | [Synonyms]
J30-8
J-30-8,J308,J30 8
2H-Indol-2-one, 3-[2-[(2-chlorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]-5-fluoro-1,3-dihydro-, (3Z)- | [Molecular Formula]
C17H9ClFN3O2S | [MDL Number]
MFCD05026464 | [MOL File]
2366255-71-0.mol | [Molecular Weight]
373.79 |
| Hazard Information | Back Directory | [Description]
J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1].
JNK3|40 nM (IC50)
| [References]
[1]. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664. |
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