| Identification | Back Directory | [Name]
PD-1-IN-22 | [CAS]
2349372-98-9 | [Synonyms]
PD-1-IN-22
PD 1 IN 22,PD1IN22
1,2,4-Triazolo[4,3-a]pyridine-8-carboxamide, N-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]-6-[[(2-hydroxyethyl)amino]methyl]- | [Molecular Formula]
C25H25N5O4 | [MDL Number]
MFCD32067983 | [MOL File]
2349372-98-9.mol | [Molecular Weight]
459.5 |
| Hazard Information | Back Directory | [Description]
PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1].
IC50: 92.3 nM (programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction)[1] PD-1-IN-22 dose-dependently elevates IFN-γ secretion in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells[1]. | [storage]
Store at -20°C | [References]
[1]. Qin M, et al. Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2019 May 9;62(9):4703-4715. |
|
|