| Identification | Back Directory | [Name]
Indium, dichloro[N,N-dimethyl-2-[(2-pyridinyl-κN)methylene]hydrazinecarbothioamide-κN2,κS]methoxy-, (OC-6-43)- | [CAS]
2345755-20-4 | [Synonyms]
Indium, dichloro[N,N-dimethyl-2-[(2-pyridinyl-κN)methylene]hydrazinecarbothioamide-κN2,κS]methoxy-, (OC-6-43)- | [Molecular Formula]
C10H16Cl2InN4OS | [MOL File]
2345755-20-4.mol | [Molecular Weight]
426.04 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 10 mg/mL,DMF:PBS (pH 7.2) (1:2): 0.30 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly Soluble | [form ]
A solid |
| Hazard Information | Back Directory | [Biological Activity]
Indium (III) thiosemicarbazone 5b is an anticancer agent.1 It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 μM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 μmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model. | [storage]
-20°C | [References]
1.Jiang, M., Chu, Y., Yang, T., et al.Developing a novel indium(III) agent based on liposomes to overcome cisplatin-induced resistance in breast cancer by multitargeting the tumor microenvironment componentsJ. Med. Chem.64(19)14587-14602(2021)
|
|
|