| Identification | Back Directory | [Name]
LEUROSINE | [CAS]
23360-92-1 | [Synonyms]
amotin
LEUROSINE
nsc-528004
Vinleurosine
Vincristine EP Impurity F
Vincristine EP Impurity F (Leurosine)
4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI
(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine
Vincristine Impurity 6(Vincristine EP Impurity F)
Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)-
Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)-
(3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine
4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin
4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin
4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester | [Molecular Formula]
C46H56N4O9 | [MDL Number]
MFCD01716248 | [MOL File]
23360-92-1.mol | [Molecular Weight]
808.97 |
| Safety Data | Back Directory | [RIDADR ]
1544 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Hazardous Substances Data]
23360-92-1(Hazardous Substances Data) | [Toxicity]
dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987. |
| Hazard Information | Back Directory | [Description]
Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals
that are best purified by recrystallization from acetonitrile. It crystallizes with 8
moles of H20 and loses solvent when heated at In-5°C. It is also dextro?
rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has
m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical
with pleurosine (q.v.). | [Uses]
Antineoplastic. | [Uses]
Vinleurosine is an antitumor compound derived from Vinca Rosea. | [Definition]
ChEBI: Leurosine is a vinca alkaloid. | [References]
Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)
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