| Identification | Back Directory | [Name]
4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-, 7-[(4-chlorophenyl)methyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester | [CAS]
2331255-53-7 | [Synonyms]
4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-, 7-[(4-chlorophenyl)methyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester | [Molecular Formula]
C22H21ClN4O5 | [MDL Number]
MFCD31814442 | [MOL File]
2331255-53-7.mol | [Molecular Weight]
456.88 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: 1 mg/ml; Chloroform: 1 mg/ml; Methyl Acetate: 1 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ABC99 is a Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme, ABC99 inhibited NOTUM with an IC50 value of 13 nM and showed excellent selectivity across the serine hydrolase family, as initially assessed by gel-based ABPP of soluble and membrane proteomes from SW620 cells. ABC99 preserves Wnt-mediated cell signaling in the presence of NOTUM and was also converted into an ABPP probe for visualizing NOTUM in native biological systems. |
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