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ChemicalBook--->CAS DataBase List--->2322293-84-3

2322293-84-3

2322293-84-3 Structure

2322293-84-3 Structure
IdentificationBack Directory
[Name]

3(4H)-Quinazolinepropanamide, 6-[5-[[(2-chloro-4-fluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-N,α-dimethyl-4-oxo-, (αS)-
[CAS]

2322293-84-3
[Synonyms]

(S)-PI3Kα-IN-4
3(4H)-Quinazolinepropanamide, 6-[5-[[(2-chloro-4-fluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-N,α-dimethyl-4-oxo-, (αS)-
[Molecular Formula]

C25H23ClFN5O5S
[MDL Number]

MFCD33402163
[MOL File]

2322293-84-3.mol
[Molecular Weight]

560
Chemical PropertiesBack Directory
[density ]

1.47±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

6.31±0.40(Predicted)
[color ]

Off-white to yellow
Hazard InformationBack Directory
[Biological Activity]

(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer[1]. (S)-PI3Kα-IN-4 (compound 11) is a quinazolin-4(3H)-one derivative with 2-substituted-N-methylpropanamide substitution[1].
[References]

[1]. Dong J, et, al. Discovery of 3-Quinazolin-4(3 H)-on-3-yl-2, N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors. ACS Med Chem Lett. 2020 Jun 10;11(7):1463-1469.
2322293-84-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
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