| Identification | Back Directory | [Name]
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide | [CAS]
2321332-57-2 | [Synonyms]
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide |
| Hazard Information | Back Directory | [Description]
CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.1 It blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines.1 CPTH6 reduces cell viability, arresting cell cycling in the G0/G1 phase and inducing apoptosis.1 It impairs autophagy in a variety of tumor cell lines, at least in part by altering ATG7-mediated elongation of autophagosomal membranes.2 | [References]
1. Trisciuoglio, D., Ragazzoni, Y., Pelosi, A., et al. CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells Clin. Cancer Res. 18(2),475-486(2012).
2. Ragazzoni, Y., Desideri, M., Gabellini, C., et al. The thiazole derivative CPTH6 impairs autophagy Cell Death Dis. 4(3),e524(2013). |
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