Identification | Back Directory | [Name]
N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine | [CAS]
230961-08-7 | [Synonyms]
UK 356618 PF-03890101 UK 356618 - PF 03890101 N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-DiMethyl-1-[[[(1R)-1-phenylethyl]aMino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-Methyl[1,1'-biphenyl]-4-yl)propyl]butanediaMide | [Molecular Formula]
C34H43N3O4 | [MDL Number]
MFCD19443865 | [MOL File]
230961-08-7.mol | [Molecular Weight]
557.72 |
Chemical Properties | Back Directory | [Melting point ]
93-102oC | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥25mg/mL | [form ]
powder | [color ]
white to tan | [optical activity]
[α]/D >+25.0°, c = 0.5 in methanol |
Hazard Information | Back Directory | [Uses]
Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). | [Definition]
ChEBI: (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide is a secondary carboxamide. |
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