| Identification | Back Directory | [Name]
4-Imidazolidinehexanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-5-methyl-2-oxo-, (4R,5S)- | [CAS]
2306109-91-9 | [Synonyms]
4-Imidazolidinehexanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-5-methyl-2-oxo-, (4R,5S)- | [Molecular Formula]
C20H40N4O6 | [MDL Number]
MFCD34471344 | [MOL File]
2306109-91-9.mol | [Molecular Weight]
432.55 |
| Chemical Properties | Back Directory | [Boiling point ]
666.0±50.0 °C(Predicted) | [density ]
1.078±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.93±0.60(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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