| Identification | Back Directory | [Name]
2-Propenamide, N-[(2,3-dichlorophenyl)methyl]-N-[4-phenoxy-3-(trifluoromethyl)phenyl]- | [CAS]
2305052-77-9 | [Synonyms]
BPK-21
2-Propenamide, N-[(2,3-dichlorophenyl)methyl]-N-[4-phenoxy-3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C23H16Cl2F3NO2 | [MOL File]
2305052-77-9.mol | [Molecular Weight]
466.28 |
| Chemical Properties | Back Directory | [Boiling point ]
519.5±50.0 °C(Predicted) | [density ]
1.365±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
-1.06±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].
BPK-21 (20 μM) significantly impairs T cellactivation[1]. BPK-21 likely suppresses T cell activation through blockadeof ERCC3 function, which may in turn act downstream or sepa-rately from pathways involved in NFAT and NF-kB activation[1]. | [storage]
Store at -20°C | [References]
[1]. Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. |
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