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Phospho-ginkgolic acid is an agonist of sphingosine-1-phosphate receptor 1 (S1P1).1 Phospho-ginkgolic acid (10 μM) induces S1P1 receptor internalization and increases ERK phosphorylation in a concentration-dependent manner in CHO cells expressing S1P1. | [References]
1. Swamy, M.M.M., Murai, Y., Ohno, Y., et al. Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor Chem. Commun. 54(90),12758-12761(2018). |
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