| Identification | Back Directory | [Name]
SD 2590 HYDROCHLORIDE | [CAS]
226395-93-3 | [Synonyms]
SD2590 HCl
SD-2590 HCl
SD 2590 HCl
SD 2590 HYDROCHLORIDE
N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride | [Molecular Formula]
C22H26ClF3N2O7S | [MDL Number]
MFCD30182243 | [MOL File]
226395-93-3.mol | [Molecular Weight]
554.96 |
| Hazard Information | Back Directory | [Description]
SD 2590 is an inhibitor of matrix metalloproteinase-2 (MMP-2), -3, -8, -9, and -13 (IC50s = <0.1, 28.7, 1.7, 0.18, and <0.1 nM, respectively). It is selective for these MMPs over MMP-1 and MMP-7 (IC50s = >10,000 and 7,000 nM, respectively). SD 2590 (10 mg/kg per day) inhibits dilation of the left ventricle in rats following myocardial infarction (MI) compared to MI vehicle control animals. | [Uses]
SD 2590 Hydrochloride is an orally active MMP inhibitor with efficacy in cancer, arthritis and cardiovascular disease. | [storage]
Store at -20°C |
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