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ChemicalBook--->CAS DataBase List--->2260905-08-4

2260905-08-4

2260905-08-4 Structure

2260905-08-4 Structure
IdentificationBack Directory
[Name]

Tauro-α-muricholic acid sodium salt
[CAS]

2260905-08-4
[Synonyms]

[Molecular Formula]

C26H46NNaO7S
[MOL File]

2260905-08-4.mol
[Molecular Weight]

539.7
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10 mg/mL; DMSO: 10 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 1 mg/mL
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1 TαMCA is common in rodents but has also been found in small amounts in human serum.2
[References]

1. Sayin, S.I., Wahlstr?m, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17(2),225-235(2013).
2. García-Ca?averas, J.C., Donato, M.T., Castell, J.V., et al. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method J. Lipid Res. 53(10),2231-2241(2012).
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