| Identification | Back Directory | [Name]
HOOCCH2CH2-PEG16-CH2CH2COOH | [CAS]
2226897-74-9 | [Synonyms]
Di-Acid-PEG17
HOOCCH2CH2-PEG16-CH2CH2COOH
4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52-Heptadecaoxapentapentacontanedioic acid | [Molecular Formula]
C38H74O21 | [MDL Number]
MFCD21363297 | [MOL File]
2226897-74-9.mol | [Molecular Weight]
866.98 |
| Hazard Information | Back Directory | [Biological Activity]
Bis-PEG17-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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