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ChemicalBook--->CAS DataBase List--->222412-82-0

222412-82-0

222412-82-0 Structure

222412-82-0 Structure
IdentificationBack Directory
[Name]

di(Atorvastatin-d5) CalciuM Salt
[CAS]

222412-82-0
[Synonyms]

[2H5]-Atorvastatin Calcium
Atorvastatin calcium salt-[d5]
di(Atorvastatin-d5) CalciuM Salt
Atorvastatin D5 calciumQ: What is Atorvastatin D5 calcium Q: What is the CAS Number of Atorvastatin D5 calcium Q: What is the storage condition of Atorvastatin D5 calcium Q: What are the applications of Atorvastatin D5 calcium
[Molecular Formula]

C132H122Ca3D10F4N8O20-2
[MOL File]

222412-82-0.mol
[Molecular Weight]

2356.79
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 0.50 mg/ml
[form ]

A solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

di(Atorvastatin-d5) Calcium Salt is the labeled analogue of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
[Biological Activity]

Atorvastatin-d5 is intended for use as an internal standard for the quantification of atorvastatin by GC- or LC-MS. Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively.1 Formulations containing atorvastatin have been used in the treatment of hypercholesterolemia and certain dyslipidemias.
[References]

1.Shaw, M.K., Newton, R.S., Sliskovic, D.R., et al.Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductaseBiochem. Biophys. Res. Commun.170(2)726-734(1990)
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