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ChemicalBook--->CAS DataBase List--->222035-13-4

222035-13-4

222035-13-4 Structure

222035-13-4 Structure
IdentificationBack Directory
[Name]

CDK2 INHIBITOR II
[CAS]

222035-13-4
[Synonyms]

SC 221409
COMPOUND 3
CDK2 INHIBITOR II
[Molecular Formula]

C14H11BrN4O3S
[MDL Number]

MFCD03456380
[MOL File]

222035-13-4.mol
[Molecular Weight]

395.23
Chemical PropertiesBack Directory
[Melting point ]

>272°C (dec.)
[density ]

1.85±0.1 g/cm3(Predicted)
[storage temp. ]

Amber Vial, -20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly, Heated)
[form ]

Solid
[pka]

8.81±0.20(Predicted)
[color ]

Light Orange to Orange
Hazard InformationBack Directory
[Description]

The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM). It is cell permeable, reversible, and ATP-competitive.
[Uses]

CDK2 inhibitor II, is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2.
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