| Identification | Back Directory | [Name]
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- | [CAS]
2210228-45-6 | [Synonyms]
SU0268
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- | [Molecular Formula]
C26H25N3O4S | [MDL Number]
MFCD34474075 | [MOL File]
2210228-45-6.mol | [Molecular Weight]
475.56 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (10 mg/ml) | [form ]
solid | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3 | [References]
Tahara et al. (2018), Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase; J. Am. Chem. Soc., 140 2105
Kant et al. (2021), Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products if Oxidatively induced DNA Base Lesions; ACS Chem. Biol., 16 45
Qin et al. (2020), Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection; J. Immunol., 205 2231 |
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DC Chemicals
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021-58447131 13564518121 |
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http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm |
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