| Identification | Back Directory | [Name]
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) | [CAS]
220701-06-4 | [Synonyms]
Fmoc-Ala-Glu-Asn-Lys-NH2
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) | [Molecular Formula]
C33H43N7O9 | [MDL Number]
MFCD32671948 | [MOL File]
220701-06-4.mol | [Molecular Weight]
681.75 |
| Chemical Properties | Back Directory | [Boiling point ]
1151.3±65.0 °C(Predicted) | [density ]
1.324±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
4.44±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1]. | [References]
[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9. |
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