| Identification | Back Directory | [Name]
2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro- | [CAS]
220568-33-2 | [Synonyms]
Br-PEG3-THP
2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro- | [Molecular Formula]
C11H21BrO4 | [MOL File]
220568-33-2.mol | [Molecular Weight]
297.19 |
| Hazard Information | Back Directory | [Biological Activity]
Bromo-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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