| Identification | Back Directory | [Name]
diphyllin | [CAS]
22055-22-7 | [Synonyms]
NSC 309691
Diphyllin >=98% (HPLC)
Diphyllin【naphthofuran】
9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one
9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one
Benz[f]isobenzofuran-1(3H)-one,9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-
Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-
4-Hydroxy-6,7-dimethoxy-9-(1,3-benzodioxole-5-yl)-1,3-dihydronaphtho[2,3-c]furan-1-one | [Molecular Formula]
C21H16O7 | [MDL Number]
MFCD00808222 | [MOL File]
22055-22-7.mol | [Molecular Weight]
380.35 |
| Chemical Properties | Back Directory | [Melting point ]
290℃ (methanol ) | [Boiling point ]
638.8±55.0 °C(Predicted) | [density ]
1.445±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
7.82±0.20(Predicted) | [color ]
white to light brown |
| Hazard Information | Back Directory | [Uses]
Diphyllin has been used to study its antibacterial and antibiofilm activities against fish pathogens. | [Definition]
ChEBI: Diphyllin is a lignan. | [General Description]
Diphyllin, a major glycoside compound, is a plant-derived lignan. It is present in Cleistanthus collinus. | [Biochem/physiol Actions]
Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities. It is a potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts. | [in vivo]
Diphyllin (20 mg/kg; oral; once a day; for 10 consecutive days) significantly inhibits the tumor growth of SGC7901 cells in mice, reduced tumor weight, downregulated the expression of V-ATPase in tumor tissues, and reduced the levels of MMP-2 and MMP-9 in serum[4].
| [IC 50]
HIV-1: 0.38 μM (IC50); Vacuolar type H+-ATPase: 17 nM (IC50); Vesicular stomatitis virus (VSV) |
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