| Identification | Back Directory | [Name]
AC-YVAD-AFC | [CAS]
219137-85-6 | [Synonyms]
AC-YVAD-AFC
AC-TYR-VAL-ALA-ASP-AFC
M.W. 719.67 C33H36F3N5O10
CASPASE-1 SUBSTRATE XII, FLUOROGENIC
CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC
AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN
N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin)
Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem
4-[[4-(difluoromethyl)-2-oxochromen-7-yl]amino]-3-[2-(3-methylbutanoylamino)propanoylamino]-4-oxobutanoic acid | [Molecular Formula]
C33H36F3N5O10 | [MDL Number]
MFCD01318881 | [MOL File]
219137-85-6.mol | [Molecular Weight]
719.66 |
| Chemical Properties | Back Directory | [Melting point ]
>190°C (dec.) | [Boiling point ]
1084.6±65.0 °C(Predicted) | [density ]
1.416±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO (Slightly), Methanol (Silghtly) | [form ]
powder | [pka]
4.09±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Description]
Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. | [Uses]
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research. | [Definition]
ChEBI: Ac-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin is a tetrapeptide obtained by formal condensation of the C-terminal carboxy group of Ac-Tyr-Val-Ala-Asp with the amino group of 7-amino-4-trifluoromethylcoumarin. It has a role as a protease inhibitor. It is a tetrapeptide, a member of acetamides, a member of coumarins and an organofluorine compound. It is functionally related to a 7-amino-4-(trifluoromethyl)coumarin. | [Biological Activity]
Fluorogenic peptide substrate for caspase-1 (ICE). |
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