| Hazard Information | Back Directory | [Description]
DI-404 is a high-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members. Further optimization of DI-404 may yield a new class of therapeutics for the treatment of human diseases in which cullin 3 CRL plays a key role. |
|
|