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ChemicalBook--->CAS DataBase List--->2185795-67-7

2185795-67-7

2185795-67-7 Structure

2185795-67-7 Structure
IdentificationBack Directory
[Name]

Lenalidomide-PEG1-azide
[CAS]

2185795-67-7
[Synonyms]

Lenalidomide-PEG1-azide
[Molecular Formula]

C17H18N6O5
[MDL Number]

MFCD34469882
[MOL File]

2185795-67-7.mol
[Molecular Weight]

386.37
Chemical PropertiesBack Directory
[solubility ]

DMSO : 100 mg/mL (258.83 mM; Need ultrasonic)
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Biological Activity]

Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-PEG1-azide can be used to design a PROTAC BRD4 Degrader-2 [1].
[References]

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
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